@article {918,
	title = {Development of donor-derived prostate cancer in a recipient following orthotopic heart transplantation},
	journal = {JAMA},
	volume = {277},
	year = {1997},
	note = {Loh, E Couch, F J Hendricksen, C Farid, L Kelly, P F Acker, M A Tomaszewski, J E Malkowicz, S B Weber, B L Case Reports United states JAMA : the journal of the American Medical Association JAMA. 1997 Jan 8;277(2):133-7.},
	month = {Jan 8},
	pages = {133 - 7},
	edition = {35438},
	abstract = {OBJECTIVE: To report the development of metastatic prostate cancer in a heart transplant recipient without a primary focus in the recipient prostate gland; to present genetic evidence suggesting transplantation of the malignancy from the donor. DESIGN: Histological analysis of donor prostate and recipient prostate and rib. Molecular genetic analysis of prostate and kidney tissue from the donor and peripheral blood leukocytes and rib tissue from the transplant recipient. SETTING: University of Pennsylvania Medical Center. RESULTS: Multiple biopsies of recipient prostate were negative for malignancy but recipient rib contained prostatic adenocarcinoma with osteoblastic bone response. Molecular genetic analysis of recipient rib specimen, which contained both histologically normal and neoplastic cells, was shown to contain a combination of alleles from the donor and recipient at 4 loci. CONCLUSION: Although this is a single case report of an uncommon event, genotyping of polymorphic dinucleotide repeat elements from 4 different chromosomal regions provides strong evidence that the tumor cells arose from donor tissue and were transplanted along with the cardiac allograft.},
	keywords = {*Adenocarcinoma / etiology / genetics / pathology / secondary, *Bone Neoplasms / etiology / genetics / pathology / secondary, *Chromosomes, Human, Pair 17, *Heart Transplantation / adverse effects, *Lymphatic Metastasis / genetics / pathology, *Prostatic Neoplasms / etiology / genetics / pathology, *Tissue Donors, Alleles, Biopsy, DNA, Neoplasm / *analysis, Genetic Markers, Genotype, Humans, Immunohistochemistry, Kidney / pathology, Leukocytes, Mononuclear / cytology, Male, Middle Aged, Prostate / pathology, Ribs / pathology},
	issn = {0098-7484 (Print) 0098-7484 (Linking)},
	author = {Loh,E. and Couch,F. J. and Hendricksen,C. and Farid,L. and Kelly,P. F. and Acker,M. A. and Tomaszewski,J. E. and Malkowicz,S. B. and Weber,B. L.}
}
