@article {659,
	title = {Donation of stem cells from blood or bone marrow: results of a randomised study of safety and complaints},
	journal = {Bone Marrow Transplantation},
	volume = {29},
	year = {2002},
	note = {HPC 0268-3369},
	month = {Mar},
	pages = {479 - 486},
	abstract = {Biological consequences and physical complaints were compared for donors randomly assigned either to blood stem cell (BSC) or bone marrow (BM) donation. In the period 1994-1999, 61 consecutive donors were included. The BSC donors were given G-CSF 10 mug/kg s.c., daily during 5 days before the first leukapheresis. Nineteen donors had one leukapheresis, 10 required two and one donor needed three leukaphereses in order to reach the target cell number of 2 X 10(6) CD34(+) cells/kg bw of the recipient. A median platelet nadir of 102 X 10(9)/1 was reached shortly after the last leukapheresis. Three weeks post harvest, 17 of 30 BSC donors had a mild leukopenia. Six had a leukopenia lasting more than a year before returning to normal values. Both groups were monitored prospectively through a standardised questionnaire completed by the donors. BSC donation was significantly less burdensome than BM donation and was preferred by the donors. The short-term risks of BSC mobilisation and harvest seem negligible. The potential long-term effects of G-CSF are unresolved and the donors must be followed closely.},
	author = {Heldal,D. and Brinch,L. and Tjonnfjord,G. and Solheim,B. G. and Egeland,T. and Gadeholt,G. and Albrechtsen,D. and Aamodt,G. and Evensen,S. A.}
}
