@article {500,
	title = {Differences between graft product and donor side effects following bone marrow or stem cell donation},
	journal = {Bone Marrow Transplantation},
	volume = {32},
	year = {2003},
	note = {HPC 0268-3369},
	month = {Nov},
	pages = {873 - 880},
	abstract = {We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM trans plantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34(+) cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34(+) cells, 5.8 x 10(6)/kg vs 2.7 x 10(6)/kg; T cells, 300.1 x 10(6)/kg vs 35.7 x 10(6)/kg; NK cells, 28.2 x 10(6)/kg vs 3.6 x 10(6)/kg; P < 0.001 for each). In connection with the cell collection procedures, PBSC donors spent a shorter median time in hospital than BM donors (0 vs 2 days; median difference -2 days, 95\% CI -2 to 2) and had fewer median days of restricted activity (2 vs 6 days; median difference -3 days, 95\% CI -4 to 2). Overall, 65\% of PBSC donors and 57\% of BM donors reported at least one adverse event (AE), most of which were transient, mild-moderate in severity, and without clinical sequelae. PBSC donors experienced predominantly filgrastim-related AEs, while BM donors experienced predominantly harvest-related AEs.},
	author = {Favre,G. and Beksac,M. and Bacigalupo,A. and Ruutu,T. and Nagler,A. and Gluckman,E. and Russell,N. and Apperley,J. and Szer,J. and Bradstock,K. and Buzyn,A. and Matcham,J. and Gratwohl,A. and Schmitz,N.}
}
