@article {359,
	title = {Red cell aplasia due to host type isohemagglutinins with exuberant red cell progenitor production of donor type in an ABO-mismatched allogeneic bone marrow transplant recipient},
	journal = {Eur J Haematol},
	volume = {43},
	year = {1989},
	note = {Cockerill, K J Lyding, J Zander, A R Case Reports Denmark European journal of haematology Eur J Haematol. 1989 Sep;43(3):195-200.},
	month = {Sep},
	pages = {195 - 200},
	edition = {32752},
	abstract = {ABO-mismatched bone marrow transplants have resulted in delayed red cell production in patients who have persistently elevated anti-ABO isohemagglutinin titers. We present a patient with chronic myelogenous leukemia who received an HLA-matched, ABO-incompatible bone marrow transplant from his sister. Post-transplant, he developed pure red cell aplasia with exuberant production of donor red cell precursors by in vitro BFU-E assay. Restriction fragment length polymorphism (RFLP) analysis of bone marrow, peripheral blood and BFU-E colonies demonstrated only donor type DNA post-transplant. However, the patient had persistently elevated isohemagglutinin titer and Ph1 chromosome-positive metaphases on chromosome analysis, indicating the presence of persistent host lymphocytes. With onset of acute graft vs. host disease (GVHD), the isohemagglutinin titer dropped, Ph1 chromosome-positive metaphases disappeared, and full hematopoietic recovery ensued. Longitudinal analysis of RFLP{\textquoteright}s, isohemagglutinin titers and chromosomes may be helpful in understanding the immunological interplay following allogeneic bone marrow transplantation.},
	keywords = {ABO Blood-Group System / *immunology, Adult, Bone Marrow Transplantation / *adverse effects, Erythroid Precursor Cells / *physiology, Graft vs Host Disease / etiology, Hemagglutinins / *analysis, Humans, Male, Philadelphia Chromosome, Red-Cell Aplasia, Pure / *etiology, Transplantation, Homologous},
	issn = {0902-4441 (Print) 0902-4441 (Linking)},
	author = {Cockerill,K. J. and Lyding,J. and Zander,A. R.}
}
