@article {278,
	title = {Simultaneous development of lymphoma in recipients of renal transplants from a single donor: donor origin confirmed by human leukocyte antigen staining and microsatellite analysis},
	journal = {Transplantation},
	volume = {79},
	year = {2005},
	note = {Caillard, Sophie Pencreach, Erwan Braun, Laura Marcellin, Luc Jaegle, Marie-Lorraine Woehl Wolf, Philippe Parissiadis, Anne Hannedouche, Thierry Gaub, Marie-Pierre Moulin, Bruno Case Reports United States Transplantation Transplantation. 2005 Jan 15;79(1):79-84.},
	month = {Jan 15},
	pages = {79 - 84},
	edition = {38400},
	abstract = {BACKGROUND: Posttransplant lymphoproliferative disorders (PTLD) occur in 0.5\% to 2.5\% of cases in renal-transplant recipients. Epstein-Barr virus (EBV) is usually detected in the tumor cells, suggesting a role for this virus as an agent of B-cell proliferation. It is unusual for patients receiving allografts from the same donor to develop PTLD simultaneously. METHODS: we describe two patients who received renal allografts from the same donor and developed PTLD simultaneously. The presence of EBV in both tumors was confirmed. In this report, the origin of tumor cells was determined by immunohistochemical human leukocyte antigen (HLA) typing and microsatellite analysis. Clonality was studied by immunoglobulin gene rearrangement analysis. RESULTS: Our results suggest that the tumor originated from donor cells in both patients but, because immunoglobulin gene rearrangements were different, this could mean that lymphoid cells proliferate independently in each recipient. CONCLUSIONS: We propose the following pathogenesis: immortalization of passenger B lymphocytes by EBV, proliferation of these cells, and development of PTLD by means of immunosuppression, antigenic stimulation, and HLA mismatch.},
	keywords = {*Microsatellite Repeats, *Tissue Donors, Adult, Female, Gene Rearrangement, Genes, Immunoglobulin, HLA Antigens / *analysis, Humans, Immunohistochemistry, Kidney Transplantation / *adverse effects, Lymphoma / *etiology, Male, Middle Aged},
	issn = {0041-1337 (Print) 0041-1337 (Linking)},
	doi = {00007890-200501150-00013 [pii]},
	author = {Caillard,S. and Pencreach,E. and Braun,L. and Marcellin,L. and Jaegle,M. L. and Wolf,P. and Parissiadis,A. and Hannedouche,T. and Gaub,M. P. and Moulin,B.}
}
