@article {162,
	title = {Haematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: report from the Research on Adverse Drug Events and Reports (RADAR) project},
	journal = {British Journal of Haematology},
	volume = {135},
	year = {2006},
	note = {HPC Bennett CL Evens AM Andritsos LA Balasubramanian L Mai M Fisher MJ Kuzel TM Angelotta C McKoy JM Vose JM Bierman PJ Kuter DJ Trifilio SM Devine SM Tallman MS Comment in: Br J Haematol. 2007 Apr;137(1):78-9; author reply 79-80; PMID: 17359374], Comment in: Br J Haematol. 2006 Dec;135(5):651-2; PMID: 17054429], Comment in: Br J Haematol. 2007 Apr;137(1):77-8; author reply 79-80; PMID: 17359373] Case Reports Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov{\textquoteright}t},
	month = {Dec},
	pages = {642 - 50},
	abstract = {Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) and granulocyte colony-stimulating factor (G-CSF) promote haematopoietic progenitor cell maturation. We reviewed the findings for healthy volunteers/donors who developed haematological malignancies following PEG-rHuMGDF or G-CSF administration. Information was reviewed for three of 538 volunteers who received PEG-rHuMGDF in clinical trials and two of 200 donors who underwent G-CSF mobilised stem cell harvesting procedures for sibling stem cell transplants. Mantle cell, diffuse large B-cell lymphoma and chronic lymphocytic leukaemia were diagnosed 1-5 years after PEG-rHuMGDF exposure among three volunteers. For one patient, thrombocytopenia due to autoantibodies to PEG-rHuMGDF developed shortly after PEG-rHuMGDF administration and persisted until chemotherapy was administered. All three achieved complete remission, although one patient relapsed. Acute myeloid leukaemia was diagnosed 4 and 5 years after G-CSF mobilisation in two donors who underwent peripheral blood stem cell donation for sibling allogeneic haematopoietic stem cell transplantation. Following intensive chemotherapy, one died from acute leukaemia and the second is in complete remission. Controversy exists over the appropriateness of administering haematopoietic growth factors to healthy individuals. While a causal relationship with haematological malignancies cannot be demonstrated, long-term follow-up among healthy individuals who receive haematopoietic growth factors is needed.},
	author = {Bennett,Charles L. and Evens,Andrew M. and Andritsos,Leslie A. and Balasubramanian,Lakshmi and Mai,Mark and Fisher,Matthew J. and Kuzel,Timothy M. and Angelotta,Cara and McKoy,June M. and Vose,Julie M. and Bierman,Philip J. and Kuter,David J. and Trifilio,Steven M. and Devine,Steven M. and Tallman,Martin S.}
}
