@article {105,
	title = {MALToma: a Helicobacter pylori-associated malignancy in transplant patients: a report from the Israel Penn International Transplant Tumor Registry with a review of published literature},
	journal = {Transplantation},
	volume = {75},
	year = {2003},
	note = {0041-1337 (Print) Case Reports Journal Article},
	month = {Jan 27},
	pages = {225 - 8},
	abstract = {BACKGROUND: Mucosa-associated lymphoid tissue lymphoma (MALToma) is a Helicobacter pylori-related tumor of B-cell origin, the malignant potential for which remains to be defined in immunosuppressed patients. METHODS: Review of the Israel Penn International Transplant Tumor Registry identified six cases of gastric MALToma. Patient demographics, management, and outcomes were compared and published literature was reviewed. RESULTS: MALToma developed in six transplant recipients (three kidney, two heart, one kidney-pancreas). All were treated with immunosuppression minimization and therapy for H. pylori, resulting in disease regression in five patients. One patient developed progression to high-grade MALToma despite documented H. pylori eradication, required surgery and chemotherapy, and died, with significant disease at autopsy. CONCLUSIONS: Treatment of MALToma with immunosuppression minimization and anti-H. pylori therapy results in a majority of patients becoming disease free. Observation of malignant degeneration into an aggressive, high-grade lymphoma in one patient indicates the malignant potential. Diligent follow-up of these patients with endoscopy and biopsy is therefore indicated.},
	keywords = {*Helicobacter pylori, Adult, Female, Heart Transplantation / adverse effects, Helicobacter Infections / *complications, Humans, Kidney Transplantation / adverse effects, Liver Transplantation / adverse effects, Lymphoma, Mucosa-Associated Lymphoid Tissue / *etiology, Middle Aged, Organ Transplantation / *adverse effects},
	author = {Aull,M. J. and Buell,J. F. and Peddi,V. R. and Trofe,J. and Beebe,T. M. and Hanaway,M. J. and Roy-Chaudhury,P. and Alloway,R. R. and First,M. R. and Woodle,E. S.}
}
