@article {5112,
	title = {The Impact of Culturing the Organ Preservation Fluid on Solid Organ Transplantation: A Prospective Multicenter Cohort Study.},
	volume = {6},
	year = {2019},
	abstract = {Background: We analyzed the prevalence, etiology, and risk factors of culture-positive preservation fluid and their impact on the management of solid organ transplant recipients.

Methods: From July 2015 to March 2017, 622 episodes of adult solid organ transplants at 7 university hospitals in Spain were prospectively included in the study.

Results: The prevalence of culture-positive preservation fluid was 62.5\% (389/622). Nevertheless, in only 25.2\% (98/389) of the cases were the isolates considered "high risk" for pathogenicity. After applying a multivariate regression analysis, advanced donor age was the main associated factor for having culture-positive preservation fluid for high-risk microorganisms. Preemptive antibiotic therapy was given to 19.8\% (77/389) of the cases. The incidence rate of preservation fluid-related infection was 1.3\% (5 recipients); none of these patients had received preemptive therapy. Solid organ transplant (SOT) recipients with high-risk culture-positive preservation fluid receiving preemptive antibiotic therapy presented both a lower cumulative incidence of infection and a lower rate of acute rejection and graft loss compared with those who did not have high-risk culture-positive preservation fluid. After adjusting for age, sex, type of transplant, and prior graft rejection, preemptive antibiotic therapy remained a significant protective factor for 90-day infection.

Conclusions: The routine culture of preservation fluid may be considered a tool that provides information about the contamination of the transplanted organ. Preemptive therapy for SOT recipients with high-risk culture-positive preservation fluid may be useful to avoid preservation fluid-related infections and improve the outcomes of infection, graft loss, and graft rejection in transplant patients.},
	doi = {10.1093/ofid/ofz180},
	author = {Oriol, I and Sabe N and C{\`a}mara, J and Berbel, D and Ballesteros, MA and Escudero, R and Lopez-Medrano, F and Linares, L and Len, O and Silva, JT and Oliver, E and Soldevila, L and P{\'e}rez-Recio, S and Guillem, LL and Camprub{\'\i}, D and LLad{\'o}, L and Manonelles, A and Gonz{\'a}lez-Costello, J and Dom{\'\i}nguez, MA and Fari{\~n}as, MC and Lavid, N and Gonz{\'a}lez-Rico, C and Garcia-Cuello, L and Arnaiz de Las Revillas, F and Fort{\'u}n, J and Aguado, JM and Jimenez-Romero, C and Bodro, M and Almela, M and Paredes, D and Moreno, A and P{\'e}rez-Cameo, C and Mu{\~n}oz-Sanz, A and Blanco-Fern{\'a}ndez, G and Cabo-Gonz{\'a}lez, JA and Garc{\'\i}a-L{\'o}pez, JL and Nu{\~n}o, E and Carratala, J}
}
