@article {5108,
	title = {Clinical prevalence and outcome of cardiovascular events in the first 100 days postallogeneic hematopoietic stem cell transplant},
	volume = {106},
	year = {2021},
	month = {Jan},
	pages = {2},
	abstract = {Introduction: Recent advances in allogeneic hematopoietic stem cell transplant (HSCT) have allowed us to offer HSCT to older, advanced disease patients with more co-morbidities. Cardiovascular toxicity post-transplant is a major concern due to the increased risk of mortality. Few studies have examined the prevalence of CV events including CAD (MI, angina, PCI, CABG, CHF, arrhythmias), HTN, stroke/TIA, and death in the first 100 days post-transplant.
Patients: We assessed the impact of pretransplant MUGA results in predicting postallogeneic HSCT CV events and overall survival in the first 100 days, and whether or not transient anthracycline-induced cardiomyopathy or cumulative anthracycline dose affected overall survival. This retrospective, cohort study included 665 patients with a median age of 52 years who underwent HSCT from 2009 to 2015.
Results: The most frequent CV event in the first 100 days post-HSCT was arrhythmia seen in 2.9\% of patients followed up by CHF (12.3\%), MI (9\%), and angina (8\%). Two patients had PCI, and both survived the first 100 days. Cardiovascular risk factors predict for a poor MUGA scan but not survival. Higher dose anthracycline pretransplant predicted for a poor outcome.
Conclusion: A history of CV disease, MI, or CAD was the most important predictive of CV events, P-value = .00002. 88.6\% survived the first 100 days. Patients with an EF < 50\% had a significant likelihood of having a CV event compared to patients with an EF > 60\% (OR = 5.3, 95\% CI [1.6-18.1], P = .0219). Cumulative anthracycline dose did not have a significant impact on overall survival.},
	doi = {10.1111/ejh.13482},
	author = {Alblooshi, R and Kanfar, S and Lord, B and Atenafu, EG and Michelis, FV and Pasic, I and Gerbitz, A and Al-Shaibani, Z and Viswabandya, A and Kim, DDH and Lam, W and Law, A and Mattsson, J and Kumar, R and Lipton, JH}
}
