@article {5048,
	title = {Malignancies in Deceased Organ Donors: The Spanish Experience.},
	volume = {106},
	year = {2022},
	month = {September},
	abstract = {Background: To better define the risk of malignancy transmission through organ transplantation, we review the Spanish experience on donor malignancies.

Methods: We analyzed the outcomes of recipients of organs obtained from deceased donors diagnosed with a malignancy during 2013-2018. The risk of malignancy transmission was classified as proposed by the Council of Europe.

Results: Of 10 076 utilized deceased donors, 349 (3.5\%) were diagnosed with a malignancy. Of those, 275 had a past (n = 168) or current (n = 107) history of malignancy known before the transplantation of organs into 651 recipients. Ten malignancies met high-risk criteria. No donor-transmitted cancer (DTC) was reported after a median follow-up of 24 (interquartile range [IQR]: 19-25) mo. The other 74 donors were diagnosed with a malignancy after transplantation. Within this group, 64 donors (22 with malignancies of high or unacceptable risk) whose organs were transplanted into 126 recipients did not result in a DTC after a median follow-up of 26 (IQR: 22-37) mo, though a prophylactic transplantectomy was performed in 5 patients. The remaining 10 donors transmitted an occult malignancy to 16 of 25 recipients, consisting of lung cancer (n = 9), duodenal adenocarcinoma (n = 2), renal cell carcinoma (n = 2), extrahepatic cholangiocarcinoma (n = 1), prostate cancer (n = 1), and undifferentiated cancer (n = 1). After a median follow-up of 14 (IQR: 11-24) mo following diagnosis, the evolution was fatal in 9 recipients. In total, of 802 recipients at risk, 16 (2\%) developed a DTC, which corresponds to 6 cases per 10 000 organ transplants.

Conclusions: Current standards may overestimate the risk of malignancy transmission. DTC is an infrequent but difficult to eliminate complication.},
	doi = {10.1097/TP.0000000000004117},
	author = {Mahillo, B and Mart{\'\i}n, S and Molano, E and Navarro, A and Castro, P and Pont, T and Andr{\'e}s, A and Gal{\'a}n, J and L{\'o}pez, M and Oliver, E and Martinez, A and Mosteiro, F and Roque, R and P{\'e}rez-Redondo, M and Cid-Cumplido, M and Ballesteros, MA and Daga, D and Quind{\'o}s, B and Sancho, M and Royo-Villanova, M and Bernab{\'e}, E and Mu{\~n}oz, R and Chac{\'o}n, JI and Coll, E and Dominguez-Gil, B}
}
