@article {4811,
	title = {Hemolytic transfusion reactions after administration of intravenous immune (gamma) globulin: a case series analysis},
	volume = {48},
	year = {2008},
	month = {Aug},
	pages = {598},
	abstract = {BACKGROUND:  This case series summarizes our observations of hemolytic reactions after the administration of large amounts of intravenous immune (gamma) globulin (IVIG). STUDY DESIGN AND METHODS:  Cases of hemolysis were identified by a decrease in hemoglobin not otherwise explained following IVIG administration. RESULTS:  Sixteen cases were identified over a 2 1/2-year period at the Ottawa Hospital of approximately 1000 patients receiving IVIG (1.6\%). Characteristics of these patients include a large dose of IVIG, female sex, non-O blood group, and underlying inflammatory state. CONCLUSIONS:  Significant hemolysis may occur after the administration of large doses of IVIG. A two-step mechanism of hemolysis is proposed, sensitization by ABO isohemagglutinins followed by phagocytosis by activated macrophages. A simple protocol to facilitate the early detection of such cases is presented.},
	author = {Daw, Z and Padmore, R and Neurath, D and Cober, N and Tokessy, M and Desjardins, D and Olberg, B and Tinmouth, A and Giulivi, A}
}
