@article {4658, title = {Donor derived Kaposi{\textquoteright}s sarcoma in a liver-kidney transplant recipient}, year = {2017}, month = {Sep}, abstract = {Human herpes virus 8 (HHV-8), also known as Kaposi{\textquoteright}s sarcoma associated herpesvirus (KSHV), is an oncogenic virus that can cause Kaposi{\textquoteright}s sarcoma (KS). KS can develop following organ transplantation through reactivation of the recipient{\textquoteright}s latent HHV-8 infection, or less commonly through donor-derived infection which has higher risk for severe illness and mortality. We describe a case of probable donor-derived KS in the recipient of a liver-kidney transplant. The donor had multiple risk factors for HHV-8 infection. The KS was successfully treated by switching immunosuppression from tacrolimus to sirolimus. With an increasing number of human immunodeficiency virus (HIV)-positive persons seeking organ transplantation and serving as organ donors for HIV-positive recipients, HHV-8 prevalence among donors and recipients will likely increase and with that the risk for post-transplant KS. Predetermination of HHV-8 status can be useful when considering organ donors and recipients with risk factors, although there are currently no validated commercial tests for HHV-8 antibody screening.}, keywords = {cancer / malignancy / neoplasia, clinical research / practice, infection and infectious agents, infectious disease, Kaposi{\textquoteright}s sarcoma, viral: human herpesvirus 8 (HHV-8)}, doi = {10.1111/ajt.14516}, author = {Dollard, SC and Douglas, D and Basavaraju, SV and Schmid, DS and Kuehnert, M and Aqel, B} }