@article {4593,
	title = {Herpes simplex virus-2 transmission following solid organ transplantation: Donor-derived infection and transplantation from prior organ recipients.},
	journal = {Transplant infectious disease : an official journal of the Transplantation Society//Transpl Infect Dis},
	year = {2017},
	month = {2017},
	address = {Denmark},
	abstract = {BACKGROUND: Owing to limited availability of donor organs, previous solid organ transplant (SOT) recipients are increasingly considered as potential organ donors. We report donor-derived transmission of herpes simplex virus type-2 (HSV-2) to two clusters of SOT recipients with transmission from the original donor and an HSV-2-infected recipient who subsequently became a donor., METHODS: We reviewed medical records of the donors and recipients in both clusters. Pre-transplant serology and virological features of HSV-2 were characterized. Genotyping of HSV-2 isolates to determine potential for donor transmission of HSV-2 through transplantation of organs from prior organ recipients was performed., RESULTS: A kidney-pancreas recipient died day 9 post transplant. Following confirmation of brain death, the lungs and recently transplanted kidney were donated to two further recipients. The liver was not retrieved, but biopsy confirmed HSV-2 infection. Testing on the original donor showed negative HSV-2 polymerase chain reaction and HSV immunoglobulin (Ig)M, but positive HSV-2 IgG. The liver recipient from the original donor developed HSV-2 hepatitis and cutaneous infection that responded to treatment with intravenous acyclovir. In the second cluster, lung and kidney recipients both developed HSV-2 viremia that was successfully treated with antiviral therapy. Genotyping of all HSV-2-positive samples showed 100\% sequence homology for three recipients., CONCLUSIONS: Donor-derived HSV infection affected two clusters of recipients because of transplantation of organs from a prior organ recipient. HSV should be considered as a possible cause of illness in febrile SOT recipients in the immediate post-transplant period and may cause disseminated disease and re-infection in HSV-2-seropositive recipients. Testing of HSV serology and prophylaxis may be considered in SOT recipients not receiving cytomegalovirus prophylaxis.Copyright {\textcopyright} 2017 John Wiley \& Sons A/S. Published by John Wiley \& Sons Ltd.},
	isbn = {1399-30621398-2273},
	author = {Macesic, Nenad and Abbott, Iain J and Kaye, Matthew and Druce, Julian and Glanville, Allan R and Gow, Paul J and Hughes, Peter D and Korman, Tony M and Mulley, William R and O{\textquoteright}Connell, Phillip J and Opdam, Helen and Paraskeva, Miranda and Pitman, Matthew C and Setyapranata, Stella and Rawlinson, William D and Johnson, Paul D R}
}
