@article {4578,
	title = {Transfusion-related alloimmune neutropenia with no pulmonary complications: one donor-five cases.},
	journal = {Transfusion//Transfusion},
	volume = {56},
	year = {2016},
	month = {2016},
	pages = {84 - 90},
	address = {United States},
	abstract = {BACKGROUND: Neutrophil alloantibodies are well-known triggers of transfusion-related acute lung injury (TRALI) and also cause immune neutropenia. Alloimmune neutropenia due to transfusion is an isolated phenomenon that is only rarely identified. Its incidence is specified in the literature as being less than one in 10,000 transfused plasma-containing units. We expect that this phenomenon is underreported., STUDY DESIGN AND METHODS: We observed five cases of alloimmune neutropenia with no respiratory complications with only one case initially reported as a suspected transfusion reaction. The other four cases were detected in the course of the subsequent lookback investigation., RESULTS: The first case was reported as a potential transfusion reaction when a female patient showed a decrease in the white blood cell count after a platelet (PLT) transfusion. Examinations of the donor blood revealed an antibody against the human neutrophil antigen HNA-1b; the recipient was typed HNA-1b positive and HNA-1a negative. After examining the blood counts of other patients who previously received PLT concentrates from the same donor, we identified four other patients with an unreported decrease in the leukocyte and/or granulocyte count of more than approximately 50\% after transfusion., CONCLUSION: HNA antibodies are generally regarded as potential triggers of TRALI. Here we describe an HNA antibody that reproducibly caused transfusion-related neutropenia only without pulmonary complications. Factors predisposing patients to TRALI development are widely discussed. Our case suggests that antibody characteristics are also relevant in the development of TRALI. Current measures to prevent TRALI should also prevent transfusion-related alloimmune neutropenia.Copyright {\textcopyright} 2015 AABB.},
	keywords = {*Isoantibodies/bl [Blood], *Isoantigens/im [Immunology], *Neutropenia/im [Immunology], *Platelet Transfusion/ae [Adverse Effects], *Transfusion Reaction/im [Immunology], Adult, Aged, Biomarkers/bl [Blood], Blood Donors, Female, Humans, Male, Middle Aged, Neutropenia/bl [Blood], Neutropenia/di [Diagnosis], Transfusion Reaction/bl [Blood], Transfusion Reaction/di [Diagnosis]},
	isbn = {1537-2995},
	author = {Hauck-Dlimi, Barbara and Ruppel, Renate and Zimmermann, Robert and Strobel, Julian and Reil, Angelika and Eckstein, Reinhold and Zingsem, Juergen}
}
