Creutzfeldt-Jakob disease in a pregnant woman with an implanted dura mater graft

TitleCreutzfeldt-Jakob disease in a pregnant woman with an implanted dura mater graft
Publication TypeJournal Article
Year of Publication1994
AuthorsLane KL, Brown P, Howell DN, Crain BJ, Hulette CM, Burger PC, DeArmond SJ
JournalNeurosurgery
Volume34
Issue4
Pagination737 - 9; - discussion - 739-40
Date PublishedApr
ISSN0148-396X (Print) 0148-396X (Linking)
Accession Number8008176
KeywordsAdult, Arnold-Chiari Malformation / pathology / *surgery, Atrophy, Brain / pathology, Collagen / *adverse effects, Creutzfeldt-Jakob Syndrome / diagnosis / pathology / *transmission, Female, Humans, Infant, Newborn, Male, Nerve Degeneration / physiology, Neurologic Examination, Postoperative Complications / *diagnosis / pathology, Pregnancy, Pregnancy Complications, Infectious / *diagnosis / pathology
Abstract

A 28-year-old woman with prior neurosurgery involving the placement of a cadaveric dural graft developed a rapidly progressive neurodegenerative disorder with prominent cerebellar dysfunction that was proven at autopsy to be Creutzfeldt-Jakob disease. She represents the second American to develop Creutzfeldt-Jakob disease in association with a dural graft. The unusual features of the case include the patient's initial clinical presentation with cerebellar ataxia in the absence of dementia, the widespread presence of kuru-type amyloid plaques on a histological examination of the brain, the development of clinical symptoms during pregnancy, and the subsequent delivery of a child who remains healthy at the age of 3 years.

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