Donation of stem cells from blood or bone marrow: results of a randomised study of safety and complaints

TitleDonation of stem cells from blood or bone marrow: results of a randomised study of safety and complaints
Publication TypeJournal Article
Year of Publication2002
AuthorsHeldal D, Brinch L, Tjonnfjord G, Solheim BG, Egeland T, Gadeholt G, Albrechtsen D, Aamodt G, Evensen SA
JournalBone Marrow Transplantation
Volume29
Issue6
Pagination479 - 486
Date PublishedMar
Accession NumberISI:000175018500004
Abstract

Biological consequences and physical complaints were compared for donors randomly assigned either to blood stem cell (BSC) or bone marrow (BM) donation. In the period 1994-1999, 61 consecutive donors were included. The BSC donors were given G-CSF 10 mug/kg s.c., daily during 5 days before the first leukapheresis. Nineteen donors had one leukapheresis, 10 required two and one donor needed three leukaphereses in order to reach the target cell number of 2 X 10(6) CD34(+) cells/kg bw of the recipient. A median platelet nadir of 102 X 10(9)/1 was reached shortly after the last leukapheresis. Three weeks post harvest, 17 of 30 BSC donors had a mild leukopenia. Six had a leukopenia lasting more than a year before returning to normal values. Both groups were monitored prospectively through a standardised questionnaire completed by the donors. BSC donation was significantly less burdensome than BM donation and was preferred by the donors. The short-term risks of BSC mobilisation and harvest seem negligible. The potential long-term effects of G-CSF are unresolved and the donors must be followed closely.

Short TitleDonation of stem cells from blood or bone marrow: results of a randomised study of safety and complaints
Notify Library Reference ID659

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