Differences between graft product and donor side effects following bone marrow or stem cell donation

TitleDifferences between graft product and donor side effects following bone marrow or stem cell donation
Publication TypeJournal Article
Year of Publication2003
AuthorsFavre G, Beksac M, Bacigalupo A, Ruutu T, Nagler A, Gluckman E, Russell N, Apperley J, Szer J, Bradstock K, Buzyn A, Matcham J, Gratwohl A, Schmitz N
JournalBone Marrow Transplantation
Volume32
Issue9
Pagination873 - 880
Date PublishedNov
Accession NumberISI:000186008400004
Abstract

We report graft product stem cell yields and donor safety results of a randomized multicenter study comparing allogeneic peripheral blood stem cell (PBSC) PBSC transplantation with BM trans plantation. Matched HLA-identical sibling donors (n = 329) were randomized to filgrastim-mobilized PBSC or bone marrow (BM) donation groups. Median yields per kg recipient weight of CD34(+) cells, T cells, and natural killer (NK) cells, respectively, were approximately two-fold, eight-fold, and greater than eight-fold in the PBSC group than in the BM group (CD34(+) cells, 5.8 x 10(6)/kg vs 2.7 x 10(6)/kg; T cells, 300.1 x 10(6)/kg vs 35.7 x 10(6)/kg; NK cells, 28.2 x 10(6)/kg vs 3.6 x 10(6)/kg; P

Short TitleDifferences between graft product and donor side effects following bone marrow or stem cell donation
Notify Library Reference ID500

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