Acute rejection of a cryopreserved arterial homograft.

TitleAcute rejection of a cryopreserved arterial homograft.
Publication TypeJournal Article
Year of Publication2015
AuthorsSoquet J, Chambon J-, Goffin Y, Jashari R
JournalCell and tissue banking//Cell Tissue Bank
Pagination331 - 3
Date Published2015
ISBN Number1573-6814
Other Numbers100965121
Keywords*Cryopreservation, *Femoral Artery/tr [Transplantation], *Graft Rejection/di [Diagnosis], *Graft Rejection/et [Etiology], *Thrombosis/co [Complications], *Thrombosis/su [Surgery], Acute Disease, Adult, Humans, Male, Middle Aged, Reoperation, Treatment Failure, Treatment Outcome

The use of arterial homograft is indicated especially in case of prosthetic graft infections after bypass surgery. We report the case of a patient who experienced the loss of a cryopreserved femoral artery caused by an acute rejection. This homograft had to be explanted 1 month after implantation because of an acute aneurysmal deterioration. Histology of the explanted artery showed inflammatory cells infiltration, pseudoaneurysms and necrosis. It was then replaced by a second cryopreserved femoral artery which is currently well tolerated. This first case of acute rejection of a cryopreserved artery, to our knowledge, raises again the question of the immunogenicity of cryopreserved homografts. The case report is followed by a brief discussion.

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