Rare transmission of hepatitis B virus by Dutch donors with occult infection.

TitleRare transmission of hepatitis B virus by Dutch donors with occult infection.
Publication TypeJournal Article
Year of Publication2016
AuthorsLieshout-Krikke RW, van Kraaij MG, Danovic F, Zaaijer HL
JournalTransfusion// Transfusion
Pagination691 - 8
Date Published2016//
ISBN Number1537-2995
Other Numberswdn, 0417360

BACKGROUND: To reduce the rate of transfusion-transmitted hepatitis B virus (HBV), HBV DNA testing was introduced for all Dutch blood donations in 2008, in addition to the existing screening for HBV surface antigen (HBsAg). This study describes the lookback results for repeat donors with an "HBV DNA-only" test result (HBV DNA-positive and HBsAg-negative)., STUDY DESIGN AND METHODS: From November 2008 until June 2011, a total of 2.3 million blood donations were tested for HBV DNA and 22 donors showed the HBV DNA-only profile. Four donors had early preseroconversion HBV infection, two showed suppressed infection after vaccination, and 16 donors had occult chronic HBV infection (OBI). Potentially infectious donations were traced back as far as 1992. If possible the recipients were tested for current and past HBV infection., RESULTS: A total of 416 implicated donations could be traced in blood bank records, involving 448 issued blood products. For 170 (38%) of the recipients no information was obtained from the hospitals; 196 (44%) recipients had died, and 82 (18%) were tested for HBV. Six recipients tested positive for current (n=4) or past (n=2) HBV infection. For two recipients transfusion was ruled out as the source of infection. Three patients showed HBV DNA sequences matching with the HBV in one common OBI donor. Overall, in four of 82 tested recipients (5%) HBV transmission was likely., CONCLUSION: In our lookback study HBV testing was possible in only a minority (18%) of potentially exposed recipients. A low transmission rate (5%) was observed in recipients of blood components from donors with OBI.Copyright © 2015 AABB.

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