|Title||Serologic survey for exposure following fatal Balamuthia mandrillaris infection.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Jackson BR, Kucerova Z, Roy SL, Aguirre G, Weiss J, Sriram R, Yoder J, Foelber R, Baty S, Derado G, Stramer SL, Winkelman V, Visvesvara GS|
|Journal||Parasitology research// Parasitol Res|
|Pagination||1305 - 11|
|Other Numbers||pre, 8703571|
|Keywords||*Amebiasis/bl [Blood], *Balamuthia mandrillaris/py [Pathogenicity], *Blood Donors, Adolescent, Adult, Aged, Aged, 80 and over, Amebiasis/mo [Mortality], Arizona, Cross-Sectional Studies, Encephalitis/bl [Blood], Encephalitis/mo [Mortality], Female, Gardening, Humans, Male, Middle Aged, Occupational Exposure, Risk Factors, Seroepidemiologic Studies, Soil/ps [Parasitology], Young Adult|
Granulomatous amebic encephalitis (GAE) from Balamuthia mandrillaris, a free-living ameba, has a case fatality rate exceeding 90% among recognized cases in the USA. In August 2010, a GAE cluster occurred following transplantation of infected organs from a previously healthy landscaper in Tucson, AZ, USA, who died from a suspected stroke. As B. mandrillaris is thought to be transmitted through soil, a serologic survey of landscapers and a comparison group of blood donors in southern Arizona was performed. Three (3.6%) of 83 serum samples from landscapers and 11 (2.5%) of 441 serum samples from blood donors were seropositive (p = 0.47). On multivariable analysis, county of residence was associated with seropositivity, whereas age, sex, and ethnicity were not. Exposure to B. mandrillaris, previously unexamined in North America, appears to be far more common than GAE in Southern Arizona. Risk factors for disease progression and the ameba's geographic range should be examined.
|Notify Library Reference ID||4471|
Serologic survey for exposure following fatal Balamuthia mandrillaris infection.
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