Impact of immunoreactive substances contained in apheresis platelet concentrate on postoperative respiratory function in surgical patients receiving platelet transfusion: a prospective cohort study.

TitleImpact of immunoreactive substances contained in apheresis platelet concentrate on postoperative respiratory function in surgical patients receiving platelet transfusion: a prospective cohort study.
Publication TypeJournal Article
Year of Publication2013
AuthorsKanai R., Iijima T., Hashimoto S., Nakazawa H., Ohnishi H., Yorozu T., Ohkawa R., Nojiri T., Shimizu M., Okazaki H.
Journal//Transfus Med
Volume23
Issue5
Pagination344 - 350
Date Published2013
ISBN Number0958-7578
Other Numbersbu7, 9301182
Keywordsanti-HLA antibody, LPC, platelet, platelet concentrate, pulmonary distress, TACO, TRALI, transfusion
Abstract

Objectives: To construct an alternative policy for the donor selection of platelet concentrate (PC), a clinical study exploring the features of lung injury following PC administration is needed., Background: Although a male-donor-only policy for plasma products appears to have efficiently reduced transfusion-related acute lung injury (TRALI), this policy may not be applied to PC because of supply shortages., Methods and Materials: We prospectively examined pulmonary function after the transfusion of PC in informed surgical patients treated at a tertiary university hospital in Japan. The contributions of immunoreactive substances contained in the PC to respiratory function after PC transfusion was then statistically examined., Results: Eighty-six patients (56 men, 30 women) were enrolled in the analysis. Fifty-four cases experienced respiratory failure (PaO2/FiO2

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