West Nile virus encephalitis in organ transplant recipients: another high-risk group for meningoencephalitis and death

TitleWest Nile virus encephalitis in organ transplant recipients: another high-risk group for meningoencephalitis and death
Publication TypeJournal Article
Year of Publication2004
AuthorsDeSalvo D, Roy-Chaudhury P, Peddi R, Merchen T, Konijetti K, Gupta M, Boardman R, Rogers C, Buell J, Hanaway M, Broderick J, Smith R, Woodle ES
JournalTransplantation
Volume77
Issue3
Pagination466 - 9
Date Published42036
Accession Number14966429
Keywords*West Nile Fever, Adult, Brain / pathology, Humans, Immunosuppression / adverse effects, Kidney Transplantation / *adverse effects, Magnetic Resonance Imaging, Male, Meningoencephalitis / diagnosis / mortality / pathology / *virology, Risk Assessment
Abstract

West Nile virus infection has been spreading westward across the continental United States since 1999. Although it often presents as a mild, self-limiting viral illness, it can result in a devastating meningoencephalitis in some patient populations, particularly the elderly. We report in this article on two immunosuppressed transplant patients who developed a severe meningoencephalitis caused by mosquito-borne West Nile virus infection. Suggestions for the prevention, diagnosis, and treatment of West Nile virus infection in this patient population are described.

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