Nonmyeloablative peripheral blood stem cell transplant for T-cell prolymphocytic leukaemia complicated by fulminant haemolysis and acute renal failure at engraftment secondary to minor ABO incompatibility

TitleNonmyeloablative peripheral blood stem cell transplant for T-cell prolymphocytic leukaemia complicated by fulminant haemolysis and acute renal failure at engraftment secondary to minor ABO incompatibility
Publication TypeJournal Article
Year of Publication2005
AuthorsCurtin NJ, Schwarer AP
JournalClin Lab Haematol
Volume27
Issue3
Pagination206 - 8
Date PublishedJun
ISSN0141-9854 (Print) 0141-9854 (Linking)
Accession Number15938729
Keywords*Hemolysis, ABO Blood-Group System / *adverse effects, Blood Group Incompatibility / blood / *complications, Hematopoietic Stem Cell Transplantation / *adverse effects / methods, Humans, Kidney Failure, Acute / *etiology, Leukemia, Prolymphocytic / blood / *complications / therapy, Leukemia, T-Cell / blood / *complications / therapy, Male, Middle Aged
Abstract

We present a 54-year-old man who underwent human leucocyte antigen-identical sibling nonmyeloablative peripheral blood stem cell transplant for primary refractory T-cell prolymphocytic leukaemia (T-PLL). His clinical course was complicated by fulminant haemolysis and acute renal failure at the time of engraftment because of minor ABO incompatibility between the donor and the recipient. This case highlights the curative potential of nonmyeloablative transplantation for T-PLL as well as the potential severity of immune haemolysis secondary to minor ABO incompatibility.

DOI10.1111/j.1365-2257.2005.00690.x
Notify Library Reference ID389

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