Second malignancies after allogeneic hematopoietic stem cell transplantation: new insight and current problems

TitleSecond malignancies after allogeneic hematopoietic stem cell transplantation: new insight and current problems
Publication TypeJournal Article
Year of Publication2002
AuthorsAdes L, Guardiola P, Socie G
JournalBlood Rev
Volume16
Issue2
Pagination135 - 46
Date PublishedJun
Accession Number12127957
KeywordsHematopoietic Stem Cell Transplantation / *adverse effects, Humans, Neoplasms, Second Primary / diagnosis / *etiology / therapy, Risk Factors, Transplantation Immunology, Transplantation, Homologous / adverse effects, Tumor Virus Infections
Abstract

With increased number of patients surviving on the long term, late effect after allogeneic hematopoietic stem cell transplantation have become of major clinical importance. Among these late effect, second malignancies have increasingly been recognized in the recent years. It has been usual to divide the problem of secondary malignancies following hematopoietic stem cell transplantation into three groups, i.e. leukemia, lymphoma and solid tumors. Recent clinical and biological data on these three types of malignancies, occurring after allogeneic stem cell transplantation, are summarized in this review. We will focus here only on second malignancies after allogeneic stem cell transplantation with particular emphasis on recent development on the pathogenesis, and early diagnosis, and treatment of these transplant-related complications.

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