Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation

TitleEncephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation
Publication TypeJournal Article
Year of Publication2007
AuthorsChen-Plotkin AS, Vossel KA, Samuels MA, Chen MH
JournalNeurology
Volume68
Issue11
Pagination859 - 61
Date Published41334
Type of ArticleCase Reports
ISSN1526-632X (Electronic) 0028-3878 (Linking)
Accession Number17353475
KeywordsBrain Injuries / chemically induced / diagnosis / *etiology, Dimethyl Sulfoxide / *adverse effects, Female, Humans, Male, Middle Aged, Myocardial Infarction / chemically induced / diagnosis / *etiology, Stem Cell Transplantation / *adverse effects, Stroke / chemically induced / diagnosis / *etiology
Abstract

Stem cell transplants are established therapy for hematologic and solid tumor malignancies. Known neurological complications of stem cell transplantation include CNS infection, seizures, strokes, metabolic encephalopathy, and hemorrhage. We report two cases of autologous stem cell transplantation complicated by cerebral infarction and myocardial injury. We postulate that the cryopreservative dimethyl sulfoxide may be responsible.

DOI10.1212/01.wnl.0000256716.04218.5b
Alternate JournalNeurology
Notify Library Reference ID330

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