Progressive fatal dementia (Creutzfeldt-Jakob disease) in a patient who received homograft tissue for tympanic membrane closure

TitleProgressive fatal dementia (Creutzfeldt-Jakob disease) in a patient who received homograft tissue for tympanic membrane closure
Publication TypeJournal Article
Year of Publication1990
AuthorsTange RA, Troost D, Limburg M
JournalEur Arch Otorhinolaryngol
Volume247
Issue4
Pagination199 - 201
ISSN0937-4477 (Print) 0937-4477 (Linking)
Accession Number2198064
Keywords*Tympanoplasty, Cerebral Cortex / pathology, Cialit, Creutzfeldt-Jakob Syndrome / pathology / *transmission, Humans, Male, Middle Aged, Pericardium / *transplantation, Time Factors, Tissue Preservation, Transplantation, Homologous
Abstract

We report the case history of a 54-year-old man who developed a fatal neurological disorder 4 years after a successful tympanoplasty with homograft pericardium. The final diagnosis of this case was Creutzfeldt-Jakob disease. This infectious spongiform encephalopathy is probably caused by a slow virus that can be transmitted by transplantation materials. The possible accidental transmission of Creutzfeldt-Jacob disease by the use of homograft materials in otologic surgery is discussed.

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