Safety and efficacy of allogeneic PBSC collection in normal pediatric donors: the pediatric blood and marrow transplant consortium experience (PBMTC) 1996-2003

TitleSafety and efficacy of allogeneic PBSC collection in normal pediatric donors: the pediatric blood and marrow transplant consortium experience (PBMTC) 1996-2003
Publication TypeJournal Article
Year of Publication2005
AuthorsPulsipher MA, Levine JE, Hayashi RJ, Chan KW, Anderson P, Duerst R, Osunkwo I, Fisher V, Horn B, Grupp SA
JournalBone Marrow Transplant
Volume35
Issue4
Pagination361 - 7
Date PublishedFeb
ISSN0268-3369 (Print) 0268-3369 (Linking)
Accession Number15608659
Keywords*Blood Donors, Adolescent, Child, Child, Preschool, Hematopoietic Stem Cell Mobilization / *standards / trends, Hematopoietic Stem Cell Transplantation / *standards / trends, Humans, Infant, Leukapheresis / standards / trends, Lymphocyte Transfusion / *standards / trends, Male, Safety / *standards, Transplantation, Homologous
Abstract

The use of peripheral blood stem cells (PBSC) for allogeneic transplants in adults has greatly increased. This trend is reflected in pediatrics, where healthy children increasingly are donating PBSC or donor lymphocyte infusion (DLI) via apheresis for use by ill siblings. There is a potential concern that the risks of PBSC collection may differ for pediatric donors. However, no large studies have assessed safety issues in this population. To address this need, we reviewed 218 (213 PBSC, five DLI) collections in 201 normal pediatric donors (8 months to 17 years, median 11.8 years) at 22 institutions in the Pediatric Blood and Marrow Transplant Consortium. Donors received a median of 4 days of growth factor, and mean collection yield was 9.1 x 10(6) CD34+ cells/kg recipient weight. Younger age, days of apheresis, and male gender predicted increased yield of CD34+ cells/kg donor weight. Growth factor-induced pain was mild and reported in less than 15% of patients. Most donors

DOI10.1038/sj.bmt.1704743
Notify Library Reference ID1290

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