Spleen enlargement following recombinant human granulocyte colony-stimulating factor administration for peripheral blood stem cell mobilization

TitleSpleen enlargement following recombinant human granulocyte colony-stimulating factor administration for peripheral blood stem cell mobilization
Publication TypeJournal Article
Year of Publication2003
AuthorsPicardi M, De Rosa G, Selleri C, Scarpato N, Soscia E, Martinelli V, Ciancia R, Rotoli B
JournalHaematologica
Volume88
Issue7
Pagination794 - 800
Date PublishedJul
ISSN1592-8721 (Electronic) 0390-6078 (Linking)
Accession Number12857559
KeywordsAdolescent, Adult, Female, Granulocyte Colony Stimulating Factor, Recombinant / *adverse effects, Hematopoietic Stem Cell Mobilization / *adverse effects, Humans, Leukocyte Count, Male, Middle Aged, Observer Variation, Reference Values, Splenomegaly / *chemically induced / radiography / ultrasonography, Tomography, X-Ray Computed / statistics & numerical data
Abstract

BACKGROUND AND OBJECTIVES: Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widely used to mobilize peripheral blood stem cells (PBSC) for autologous or allogeneic transplants. Such treatment may cause spleen enlargement; exceptionally, spontaneous spleen rupture has been reported. We investigated changes in spleen size during stem cell mobilization. DESIGN AND METHODS: We evaluated spleen size, comparing palpation with ultrasound (US)-evaluated longitudinal diameter and volume, in 13 healthy donors and 22 patients with a hematological malignancy who were undergoing PBSC mobilization with rhG-CSF-including regimens. RESULTS: Intraobserver and interobserver variability of US-calculated spleen volume was very low; the correlation between the volume calculated by US and that measured by 3-dimensional computed tomography was excellent. During mobilization, spleen enlargement was detected by palpation in 17% of subjects, by US-measured longitudinal diameter in 60%, and by US-calculated volume in 91%. The median increase in spleen volume was 300 mL (range, 54-820; p

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