TY - JOUR T1 - Elderly recipients of hepatitis C positive renal allografts can quickly develop liver disease. JF - The Journal of surgical research// J Surg Res Y1 - 2012 A1 - Flohr, Tanya R A1 - Bonatti, Hugo A1 - Hranjec, Tjasa A1 - Keith, Doug S A1 - Lobo, Peter I A1 - Kumer, Sean C A1 - Schmitt, Timothy M A1 - Sawyer, Robert G A1 - Pruett, Timothy L A1 - Roberts, John P A1 - Brayman, Kenneth L KW - *Hepatitis C/tm [Transmission] KW - *Kidney Failure, Chronic/su [Surgery] KW - *Kidney Transplantation/ae [Adverse Effects] KW - *Postoperative Complications/vi [Virology] KW - Adult KW - Age Factors KW - Aged KW - Female KW - Follow-Up Studies KW - Graft Rejection/dt [Drug Therapy] KW - Graft Rejection/mo [Mortality] KW - Graft Survival KW - Hepatitis C/mo [Mortality] KW - Humans KW - Immunosuppressive Agents/tu [Therapeutic Use] KW - Kaplan-Meier Estimate KW - Kidney Failure, Chronic/mo [Mortality] KW - Male KW - Middle Aged KW - Morbidity KW - Postoperative Complications/mo [Mortality] KW - Tissue Donors KW - Transplantation, Homologous KW - Young Adult AB - Our institution explored using allografts from donors with Hepatitis C virus (HCV) for elderly renal transplantation (RT). Thirteen HCV- elderly recipients were transplanted with HCV+ allografts (eD+/R-) between January 2003 and April 2009. Ninety HCV- elderly recipients of HCV- allografts (eD-/R-), eight HCV+ recipients of HCV+ allografts (D+/R+) and thirteen HCV+ recipients of HCV- allografts (D-/R+) were also transplanted. Median follow-up was 1.5 (range 0.8-5) years. Seven eD+/R- developed a positive HCV viral load and six had elevated liver transaminases with evidence of hepatitis on biopsy. Overall, eD+/R- survival was 46% while the eD-/R- survival was 85% (P = 0.003). Seven eD+/R- died during follow-up. Causes included multi-organ failure and sepsis (n = 4), cancer (n = 1), failure-to-thrive (n = 1) and surgical complications (n = 1). One eD+/R- died from causes directly related to HCV infection. In conclusion, multiple eD+/R- quickly developed HCV-related liver disease and infections were a frequent cause of morbidity and mortality.Copyright © 2012 Elsevier Inc. All rights reserved. M1 - k7b, 0376340 CY - United States VL - 176 SN - 1095-8673 CP - 2 L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=medl&NEWS=N&AN=22316669 ID - 4499 ER -