TY - JOUR T1 - Acute hemolytic transfusion reaction secondary to anti-Fy3. JF - Immunohematology / American Red Cross//IMMUNOHEMATOLOGY Y1 - 2005 A1 - Olteanu, H A1 - Gerber, D A1 - Partridge, K A1 - Sarode, R KW - *Blood Transfusion/ae [Adverse Effects] KW - *Hemolysis/im [Immunology] KW - *Isoantibodies/bl [Blood] KW - Acute Disease KW - Aged KW - Aged, 80 and over KW - Female KW - Humans KW - Isoantibodies/im [Immunology] KW - Phenotype AB - A hemolytic transfusion reaction due to anti-Fy3 is reported in an African American patient with no history of sickle cell disease. This 82-year-old African American woman received two units of RBCs for anemia (Hab 7 g/dL) on admission for a left hip fracture. On hospital Day 7, the patient underwent left hip endoprosthesis surgery; she received two units of RBCs on the second postoperative day due to Hb of 6.1 g/dL. Her urine was dark during surgery and postoperatively. Her posttransfusion plasma was red. Her Hb dropped from 8.4 to 6.4 g/dL over 24 hours after the transfusion. Her total bilirubin rose to 4.0 mg/dL, with and LDH value of 1558 U/L and a haptoglobin of 10.9 mg/dL. Both the antibody detection test and the DAT were positive. An anti-Fy3 was identified in the serum and in the eluate. To the best of our knowledge, this is the first case of acute intravascular hemolysis due to anti-Fy3 in a patient without sickle cell disease. M1 - 8806387 PB - Olteanu,H. Department of Pathology, the University of Texas Southwestern Medical Center at Dallas 75390-9073, USA. CY - United States VL - 21 SN - 0894-203X CP - 2 L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=med5&NEWS=N&AN=15981343 ID - 4242 ER -