@article {4487, title = {Donor-derived organ transplant transmission of coccidioidomycosis.}, journal = {Transplant infectious disease : an official journal of the Transplantation Society// Transpl Infect Dis}, volume = {14}, year = {2012}, month = {2012//}, pages = {300 - 4}, address = {Denmark}, abstract = {Coccidioidomycosis in solid organ transplant recipients most often occurs as a result of primary infection or reactivation of latent infection. Herein, we report a series of cases of transplant-related transmission of coccidioidomycosis from a single donor from a non-endemic region whose organs were transplanted to 5 different recipients. In all, 3 of the 5 recipients developed evidence of Coccidioides infection, 2 of whom had disseminated disease. The degree of T-cell immunosuppression and timing of antifungal therapy initiation likely contributed to development of disease and disease severity in these recipients. This case series highlights the importance of having a high index of suspicion for Coccidioides infection in solid organ transplant recipients, even if the donor does not have known exposure, given the difficulties of obtaining a detailed and accurate travel history from next-of-kin.Copyright {\textcopyright} 2011 John Wiley \& Sons A/S.}, keywords = {*Antifungal Agents/tu [Therapeutic Use], *Coccidioides/ip [Isolation \& Purification], *Coccidioidomycosis/tm [Transmission], *Fungemia/mi [Microbiology], *Organ Transplantation/ae [Adverse Effects], *Tissue Donors, Adolescent, Coccidioidomycosis/di [Diagnosis], Coccidioidomycosis/dt [Drug Therapy], Fatal Outcome, Female, Fluconazole/tu [Therapeutic Use], Fungemia/di [Diagnosis], Fungemia/dt [Drug Therapy], Humans, Immunosuppression/mt [Methods], Male, Middle Aged, T-Lymphocytes/im [Immunology], Tissue and Organ Harvesting, Travel, Young Adult}, isbn = {1399-3062}, author = {Dierberg, K L and Marr, K A and Subramanian, A and Nace, H and Desai, N and Locke, J E and Zhang, S and Diaz, J and Chamberlain, C and Neofytos, D} }