@article {4442, title = {A delayed hemolytic transfusion reaction (DHTR) with multiple alloantibodies (Anti-E, Jka, Dia, Fyb, and S) induced by E-antigen-negative, crossmatch-compatible blood.}, journal = {Immunopharmacology and immunotoxicology//Immunopharmacol Immunotoxicol}, volume = {20}, year = {1998}, month = {1998}, pages = {531 - 9}, publisher = {Yamane,K. Department of Laboratory Diagnosis, Sapporo Medical University School of Medicine, Japan.}, address = {UNITED STATES}, abstract = {We describe the case of a 44-year-old woman with a delayed hemolytic transfusion reaction (DHTR). She had a history of two pregnancies and a blood transfusion, the details of which were unknown. At the time of her first vascular surgery on November 15, 1989, she received 1200 ml of crossmatch-compatible concentrated red blood cells (CRC). Before the first operation, screening for anti-RBC antibodies (Ab) was negative. At the time of the second admission on Feburary 15, 1996, anti-E Abs were detected by indirect antiglobulin test. She received 560 ml of E-antigen-negative, crossmatch-compatible, CRC for treatment of anemia on March 1 and 2, 1996. After this transfusion, total bilirubin (1.6 mg/dl) and lactate dehydrogenase (1355 IU/ml) were elevated on March 12, 1996. She had no evidence of clinical hemolysis. We suspected DHTR from these data, and therefore screened for anti-RBC Abs. Anti-E, Jka, Dia, Fyb, and S Abs were detected in blood samples obtained from the patient on March 12, 1996. Anti-E, Jka Dia, and S Abs were present more than 1 month and anti-Fyb Ab was disappeared at 18 days after transfusion.}, keywords = {*Blood Group Incompatibility/im [Immunology], *Erythrocyte Transfusion/ae [Adverse Effects], *Hemolysis/im [Immunology], *Hepatitis B e Antigens/im [Immunology], *Isoantibodies/bi [Biosynthesis], *Isoantibodies/im [Immunology], *Kidd Blood-Group System/im [Immunology], Adult, Blood Grouping and Crossmatching, Erythrocytes/im [Immunology], Female, Hepatitis B e Antigens/bl [Blood], Humans, Isoantibodies/bl [Blood]}, isbn = {0892-3973}, author = {Yamane, K and Yagihashi, A and Sasaki, M and Kuwashima, K and Morio, A and Watanabe, N} }